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Autolus Therapeutics’ chimeric antigen receptor (CAR) T-cell therapy obecabtagene autoleucel (Aucatzyl) received FDA approval for adults with B-cell precursor acute lymphoblastic leukemia (ALL). The ...

According to research presented at the Society for the Immunotherapy of Cancer Annual Meeting in Houston, TX, the IL15 agonist NKTR-255 (Nektar Therapeutics) reverses lymphopenia caused by ...

1Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.

A new targeted therapy aimed specifically at FGFR3, TYRA-300, is showing preliminary promise in patients with advanced FGFR3-altered bladder cancer. Partial responses have been seen in an ongoing ...

Institute of TCM-X/MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, China.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Chimeric antigen receptors (CAR) enable MHC-independence but do not recreate the precise molecular regulation induced by T-cell receptor (TCR) complexes. In an effort to engage endogenous TCR circuits ...

1Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts.

1Catholic University of the Sacred Heart and Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy. Search for other works by this author on: 2Department of Oncology, Sidney Kimmel ...

1Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain. 2Navarra Institute for Health Research (IDISNA), Pamplona, Spain. 3Centro de Investigación Biomédica en Red de ...